Hello
No consumer supplement clearly lists % conessine on its packaging. Most only list extract ratio or alkaloids generally.
To know actual conessine content, you’d need to request a lab report (COA).
Some products sold under Holarrhena as a research chemical might provide higher purity conessine for laboratory studies — these are not intended for self-use or oral supplementation.
Higher potency does not always mean safer — conessine is a pharmacologically active alkaloid, and excessive doses may have side effects.
If your goal is to get the highest conessine concentration safely and practically, your best bet is a well-formulated Kutaja extract supplement (10:1 or higher) from a reputable Ayurvedic vendor — ideally with a COA showing alkaloid content. Avoid raw powders and be cautious with unregulated pure conessine offerings designed for research.
Warm Regards Dr Snehal Vidhate
Kindly mention the reason and aim behind this question so that we can answer accordingly.
I am sorry but I cannot help/ provide information regarding this
It is understandable that you’re having a difficult time finding conessine as a supplement.
Based on my research, there’s a very clear reason for this: conessine is not sold as a consumer supplement for human use.
Instead, it is a research chemical and is primarily sold to scientific laboratories for research purposes. This is an important distinction because research chemicals are not regulated by agencies like the FDA for human consumption, and their safety and efficacy have not been established in this context.
Why You Can’t Find Conessine Supplements
Primary Use: Conessine is a steroidal alkaloid found in the bark of the Holarrhena antidysenterica plant. It is primarily studied for its potential as an antibacterial, antimalarial, and histamine H3 receptor antagonist. These are all pharmacological actions that are of interest to scientists and drug developers, not for a dietary supplement.
Lack of Regulation: Because it’s not a supplement, it doesn’t have a standardized “dose” or “concentration” for human use. The products that are available are sold by chemical supply companies with a stated purity (often 97% or higher) and are explicitly labeled “for scientific research use only” to protect the seller from liability.
Safety Concerns: Research into conessine has shown it has a slightly toxic nature and can cause side effects. This is another reason it is not available for public consumption.
Finding “High-Concentration” Conessine If you are looking for the highest concentration of conessine, your search will lead you to these chemical and research supply companies. Their products are sold as a pure powder or solution, and the concentration would be based on the purity percentage listed on the label.
Again, I must strongly emphasize that these products are not meant for human consumption. They are for laboratory use, and their safety profile for humans is unknown. Any use of these products outside of a controlled, professional setting could be dangerous.
HELLO
Pure/concentrated conessine of the highest concentration you can obtain is available from chemical/research suppliers (≥98–99% pure). For “supplements” sold for human consumption, you won’t find products that consistently label high conessine content — rather the usual source is Holarrhena (kutaja) bark extracts, containing only a trace amount of conessine (literature reports ~0.4% conessine in the bark and total bark alkaloids ~1–4.7%).
Commercial Holarrhena (kutaja) supplements / extracts (the botanical source) can have conessine present, but the amount is low and highly variable, and little on product labels quantifies conessine. Literature reports bark conessine ~0.4% (and total alkaloids 1.1–4.7%). So a standard extract capsule will have many less times conessine than a gram of purified material
Safety & legal notes (significant) Purified conessine from research suppliers is not for human consumption and is marketed for in-vitro/in-vivo research. Administration of research chemicals orally or as “supplements” is risky (unknown dose, contaminants, legal/regulatory). I strongly advise you not to ingest research-grade chemicals and to consult a qualified clinician before you take anything containing conessine.
THANK YOU
DR. MAITRI ACHARYA
Kutaja holarrhena antidysenterica has conessin constituent in it
These supplements should always be taken under a doctor’s advice. Though they are supplements, dosage is always as per individual requirements.
Finding supplements with conessine can be quite challenging because it is not widely available in supplement form. Conessine is a bioactive alkaloid predominantly found in the plant Holarrhena antidysenterica, also known as Kurchi or Kutaj in Ayurveda. This plant is traditionally used in treating intestinal disorders, malabsorption issues, and as an anti-amoebic. While there mightn’t be commercially available supplements focused solely on conessine, Kutaj’s formulations might be your best bet.
Consider looking for standardized extracts of Holarrhena antidysenterica, if available, as they may contain a concentrated form of the conessine alkaloid. Check reputable sources or Ayurvedic pharmacies for Kutaj bark or seed extracts. However, be sure to carefully examine the labels or product descriptions for the concentration levels, as these details are crucial. Keep in mind the legal and health regulations in your area concerning herbal supplements, as some potent plant alkaloids may have restrictions or require prescriptions.
Moreover, the actual conessine content can vary significantly depending on the extraction method, plant part used, and manufacturer standards. If you consider exploring these formulations, it may be wise, to consult an Ayurvedic practitioner or healthcare provider. They can provide guidance on appropriate dosages, potential interactions, and holistic approaches suited to your unique constitution (prakriti) and current health state.
Also, sourcing from herbs directly, if feasible, can let you create tailored decoctions or formulations under the guidance of a skilled practitioner. This direct approach, while traditional, often assures quality and concentration but warrants expertise in preparation and dosing. Yet, as always, prioritize safety and regulatory compliance when brining in any herbal supplement into your regimen.
Conessine, a natural alkaloid, is primarily extracted from the plant Holarrhena antidysenterica, known as kurchi in traditional Ayurvedic medicine. While specific commercial supplements with a standardized high concentration of conessine are not widely available, full-spectrum powders or tincture extracts of Holarrhena antidysenterica are commonly used.
In Ayurvedic practice, rather than focusing on isolated compounds, we emphasize the synergy of whole plants to balance doshas and treat specific ailments. For digestive issues or concerns related to pitta and kapha imbalances, supplementing with Holarrhena antidysenterica in its natural form might be recommendable. To find a quality product, check for reputable herbal suppliers that provide kurchi bark powder or tinctures—making sure that they follow good harvesting and preparation practices.
Before using any supplement, it’s crucial to evaluate your body constitution (prakriti) and any conditions you might have. Since Holarrhena’s properties are cooling and drying, it may influence vata dosha if overused. Always consult with a healthcare professional or Ayurvedic practitioner for proper dosage and to ensure the herb aligns with your specific health needs. Overuse without understanding the broader context of your health could potentially disrupt your doshic balance.
