Even if he’s taken Zandopa for years, it can suddenly start causing diarrhea. This can happen because the gut becomes more sensitive over time, the dose or brand/formulation changed, or because of a new interaction with food or another medication. Parkinson’s meds like Zandopa can also speed up bowel movement or irritate the intestines. However, new, severe diarrhea is not something to ignore—especially if it happens after every dose or even after eating. Infection, inflammation, or another unrelated GI problem could also be the cause. 👉 He should contact his doctor promptly. The doctor may adjust the dose, switch formulations, or check for other causes. 🚨 Get urgent care if there’s dehydration, blood in stool, fever, or weight loss.
It has happened after every dose—even after reducing from the heaping scoop that comes with it down to a 1 teaspoon. He usually has a banana or some oatmeal before taking it. Used to take it on an empty stomach…
वो सिर्फ ज़ैंडोपा लेने के बाद ही दस्त का शिकार होता है। मैंने सोचा कि शायद कुछ खाने से मदद मिलेगी, इसलिए मैंने उसे पहले कुछ खाने को कहा… लेकिन ज़ैंडोपा बंद करने के बाद उसकी याददाश्त और सेहत दोनों ही खराब हो गई हैं।
ओह, मुझे अभी-अभी एहसास हुआ कि पिछले समर में मैं एक कार्निवोर डाइट पर थी - सिर्फ दूध, अंडे, स्टेक, चीज़ वगैरह… इससे मेरे पति के गट माइक्रोबायोम पर असर पड़ा होगा - अचानक से कोई फाइबर नहीं। हमने इस तरह कुछ महीनों तक खाया। अब मैं इसे कैसे ठीक करूं?? मुझे बहुत बुरा लग रहा है!
हर खुराक के बाद लगातार दस्त होने से शरीर में पानी की कमी, इलेक्ट्रोलाइट असंतुलन और वजन घट सकता है। यह सामान्य नहीं है कि कोई दीर्घकालिक दवा अचानक से लगातार ऐसा प्रभाव डाले।
- क्या करें: ज़ांडोपा लेना बंद करें जब तक कि एक न्यूरोलॉजिस्ट इसे रिव्यू न कर ले ओआरएस के साथ अच्छी तरह से हाइड्रेट करें मल की आवृत्ति, मात्रा, रंग को ट्रैक करें जिस डॉक्टर ने इसे सलाह दी थी, उनसे तुरंत मिलें; वे फॉर्मूलेशन, खुराक बदल सकते हैं या अन्य कारणों की जांच कर सकते हैं तब तक मैंने आपको कुछ आयुर्वेदिक दवा लिखी है जो आपकी मदद करेगी और एक एलोपैथिक - लोपेरामाइड 2 मिग्रा हर ढीले मल के बाद, अधिकतम 4/दिन – बुखार या मल में खून होने पर इसे न लें) ओआरएस को धीरे-धीरे लेते रहें
तुरंत देखभाल के लिए चेतावनी संकेत: मल में खून गंभीर पेट दर्द बुखार चक्कर आना या बेहोशी
धन्यवाद
Ok , got it due to this you can’t stop zandopa No worries, At present we can’t stop zandopa in that case , but give it in low dose right in this situation, and consult with your doctor he will give alternate option for this medicine. And what u to do now - - low dose zandopa - loperamide 2 mg after stool - max 4/day - continue with ayurveda medicine as supportive.
You can also start with - 1) Pectin / Oral Decoction (Banana, Rice Water, Cumin Water) Banana + Rice water (Kanji): Soothes gut, provides electrolytes Cumin + Fennel + Ginger decoction: 1 cup, 2–3 times daily 3. Bilva (Aegle marmelos) Powder / Tablet Dose: 500 mg , twice daily Effect: Reduces frequency of loose stools 4. Yogurt / Probiotic Lassi Effect: Restores gut flora - Cautions: Avoid heavy, oily, or very spicy foods Avoid self-medicating with strong astringent herbs like Kutaja for long-term use without practitioner guidance - Monitor for dehydration; Ayurvedic remedies are supportive but don’t replace medical evaluation if diarrhea is severe
The neurologists in our city are familiar with mucuna pruriens or Zandopa…. So there’s no one to help me with figuring this out. He has lost about 40 lbs over the past year// his appetite was really low—. He used to be a big eater-/ really enjoyed food! It’s been a hard last couple of years.
हम कोलंबिया, MO USA में रहते हैं।
it sounds really overwhelming. Losing 40 lbs in a year with worsening appetite and diarrhea is serious. This isn’t just a “med side effect” anymore; it’s now malnutrition and possible dehydration, and it’s taking a toll on both his Parkinson’s and overall health. - Why this is serious Persistent diarrhea after Zandopa → he’s losing nutrients and fluids every day. Weight loss + low appetite → puts him at high risk for weakness, infections, and worsening cognition. Stopping Zandopa worsens Parkinson’s → but continuing it causes diarrhea. This is a high-priority medical situation. Waiting for the “perfect neurologist” isn’t safe - Immediate Steps You Can Take Today Do not stop Zandopa abruptly. It’s worsening Parkinson’s symptoms. - Hydrate aggressively: ORS, coconut water, rice water. - High-calorie, soft foods if tolerated: bananas, oatmeal, yogurt, nut butters, soups. - Track stool frequency, consistency, timing after Zandopa. - Seek urgent medical attention: even a general physician or internist can help stabilize him, check labs (CBC, electrolytes, kidney function), and manage diarrhea temporarily -as advice upper ayurvedic support medicine+ loperamide - while planning neurologist follow-up. ***** If there will not any general physician also u got, kindly tell history, and where u live?
Ok , got it due to this you can’t stop zandopa No worries, At present we can’t stop zandopa in that case , but give it in low dose right in this situation, and consult with your doctor he will give alternate option for this medicine. And what u to do now - - low dose zandopa - loperamide 2 mg after stool - max 4/day - continue with ayurveda medicine as supportive.
कृपया पूरी स्थिति का विस्तार से बताएं, क्योंकि इससे सही कदम उठाने में रुकावट आ रही है। और निदान, यह कब शुरू हुआ, वह क्या ले रहा है? कोई जांच हुई है?
वो Levidopa Carbidopa CR 100/25 दिन में 1-2 बार ले रहे हैं। उन्हें दवाओं के प्रति बहुत संवेदनशीलता हो गई है और उन्हें दवा से कम से कम 1.5 घंटे पहले या बाद में प्रोटीन लेना पड़ता है। जब वो Zandopa भी ले रहे थे, तब वो उतने कमजोर या मानसिक रूप से अच्छे नहीं थे। वो लगभग 3 महीने से Zandopa नहीं ले रहे हैं… मैं ये समझने की कोशिश कर रहा हूँ कि उन्हें फिर से स्वस्थ कैसे किया जाए।
सबसे पहले शांत रहें, इससे आप तनाव में नहीं आएंगे। अगर आप ठीक रहेंगे, तो आप उनकी देखभाल कर पाएंगे। मैं समझता हूँ कि मुझे ज़ेंडोपा से परिणाम मिले हैं, लेकिन इसका मतलब यह नहीं है कि सिर्फ एक ही दवा है। कई विकल्प भी हैं, और अमेरिका में आपको बेहतरीन डॉक्टर भी मिलेंगे, जो आपको विकल्प देंगे।
वर्तमान में, उनकी मौजूदा स्थिति के अनुसार जाँच के साथ अपने प्रिस्क्रिप्शन की समीक्षा के लिए व्यक्तिगत रूप से जाएं। और ऊपर बताई गई आयुर्वेदिक दवा को भी जोड़ें। चूंकि आप वहां हैं, हम पंचकर्म प्रक्रिया नहीं कर सकते, लेकिन रोज़ाना शीरबला तेल से मालिश करें, अगर संभव हो तो पूरे शरीर पर।
Thank you so much Dr. Garg! You are very kind & I can tell a wonderful doctor.
Zandopa (Mucuna pruriens) contains L-Dopa, which can irritate the stomach and intestines. Even if he tolerated it for years, sudden diarrhea can happen due to Change in brand or dose Gut sensitivity developing with age Interaction with new medicines or foods Weak digestion / intestinal infection Taking it without proper adjuvant (like milk or food suited to him) Take Dadimastaka churnam 1tsp
मैंने अभी महसूस किया कि पिछले 2 सालों में मैंने कुछ बार कार्निवोर डाइट के साथ प्रयोग किया है। उसे भी कुछ आवेगशीलता/लत जैसी समस्याएं हो रही थीं जो उसके लिए असामान्य थीं। वह गाड़ी चलाते समय सो भी गया था, जो बहुत डरावना था — भगवान का शुक्र है कि हम ठीक हैं🙏🏻। इसलिए मैंने उसे रोपिनेरोल से हटाया और लेवोडोपा/कार्बिडोपा को कम करना शुरू किया, जबकि ज़ैंडोपा के साथ जारी रखा जो वैसे भी अधिक प्रभावी लग रहा था… उसकी दवाओं को कम करने के बाद… और बाद में पिछले 2 सालों में कुछ महीनों के लिए कार्निवोर डाइट (शायद कुल 4 महीने)।, हमारे लिए समय बहुत कठिन रहा है! वह कभी भी उतना सख्त नहीं था जितना मैं था लेकिन… चूंकि इन दिनों मैं मुख्य भोजन तैयार करने वाला व्यक्ति हूं- इसका उस पर काफी प्रभाव पड़ा होगा… मैं चाहता हूं कि हमारे अमेरिका के न्यूरोलॉजिस्ट ज़ैंडोपा और म्यूकुना प्रुरीन्स के साथ-साथ अन्य प्राकृतिक पौधों और जड़ी-बूटियों से परिचित हों🙏🏻।
मैं सच में चाहता हूं कि मैं उसे 2 साल पहले की स्थिति में वापस ले जा सकूं और मैंने इतने कठोर बदलाव न किए होते।
WHEN A MEDICINE THAT HAS BEEN USED FOR MANY YEARS SUDDENLY STARTS CAUSING DIARRHEA IT CLEARLY INDICATES THAT THE INTERNAL BALANCE OF THE BODY HAS CHANGED THIS IS NOT UNCOMMON IN LONG TERM MEDICATION USE WHERE OVER TIME THE DIGESTIVE FIRE BECOMES IRREGULAR AND THE INTESTINES TURN MORE SENSITIVE ZANDOPA ACTS ON THE NERVOUS SYSTEM AND CAN INCREASE GUT ACTIVITY WHEN AGNI BECOMES TIKSHNA OR UNSTABLE THE SAME MEDICINE CAN START CAUSING EXCESSIVE BOWEL MOVEMENTS LOOSE STOOLS AND DIARRHEA EVEN AFTER FOOD THIS IS A CLASSIC PRESENTATION OF VATAPITTA DUSHTI IN THE ANNA VAHA AND PURISHA VAHA SROTAS CHRONIC DIARRHEA WITHOUT OTHER MAJOR SYMPTOMS INDICATES FUNCTIONAL DISTURBANCE OF THE GUT RATHER THAN INFECTION THE MEDICINE IS NOW ACTING AS A TRIGGER ON A SENSITIVE DIGESTIVE SYSTEM CONTINUING IT WITHOUT CORRECTING AGNI AND GUT STABILITY CAN PROLONG THE PROBLEM FROM AN AYURVEDIC PERSPECTIVE THE FIRST AIM IS TO STABILIZE DIGESTION AND CONTROL ATIPRAVRITTI OF THE BOWELS MEDICINES THAT STRENGTHEN THE INTESTINAL MUCOSA AND NORMALIZE AGNI ARE REQUIRED AYURVEDIC MEDICINES COMMONLY USED IN SUCH CONDITIONS INCLUDE BILVA AVALEHA OR BILVADI CHURNA TO CONTROL LOOSE MOTIONS AND STRENGTHEN THE GUT GRAHANI SUPPORTING FORMULATIONS SUCH AS TAKRARISHTA TO IMPROVE DIGESTIVE STABILITY KUTAJARISHTA OR KUTAJ GHANA CAN HELP IN CHRONIC NON INFECTIVE DIARRHEA SHANKH BHASMA IN PROPER MEDICAL SUPERVISION TO REGULATE AGNI AND REDUCE HYPERACIDITY ALONG WITH MEDICINES DIETARY CORRECTION IS ESSENTIAL WARM LIGHT EASILY DIGESTIBLE FOOD AT REGULAR TIMES IS IMPORTANT COLD RAW FERMENTED OR VERY SPICY FOODS CAN WORSEN THIS CONDITION THIS DOES NOT MEAN THE CONDITION IS PERMANENT IT MEANS THE BODY IS ASKING FOR REEVALUATION OF BOTH DIGESTIVE HEALTH AND MEDICATION NEED THE DOSAGE OR TIMING OF ZANDOPA MAY NEED ADJUSTMENT AFTER CONSULTING THE TREATING DOCTOR CHRONIC DIARRHEA SHOULD NEVER BE IGNORED AS IT CAN LEAD TO WEAKNESS DEHYDRATION AND ELECTROLYTE IMBALANCE WITH PROPER AYURVEDIC MANAGEMENT FOCUSED ON GRAHANI AND AGNI BALANCE THE BOWEL MOVEMENTS CAN NORMALIZE AND OVERALL HEALTH CAN BE RESTORED
डॉ. पेंटाकोटा? क्या आपने ऊपर मेरे दवा में बदलाव और कार्निवोर डाइट के बारे में जवाब देखा? मैंने ये सब तब महसूस किया जब मैं आपका जवाब पढ़ रहा था। हम उसकी आंत को कैसे सुधारें और ऐसा खाना कैसे ढूंढें जो उसे मजबूत बनाए और उसके पाचन तंत्र में मदद करे? हम अमेरिका में हैं और जब मैंने आपकी सलाह के अनुसार कुछ खरीदने की कोशिश की तो मैं नहीं कर पाया। कृपया सलाह दें🙏🏻
HELLO, Your husband’s problem is not an infection, food poisoning, or sudden disease It is a functional digestive disorder that ha developed slowly over time WHAT ACTUALLY HAPPENED? -The digestive system works properly when the digestive fire is balanced -Long term continues use of mediicne (Zandopa) has gradually irritated the intestine and weakened digestion -Over months and years , the intestines became over-sensitive -Now whenever food or the medicine enters –the intestine reacts too fast –water is not absorbed properly –stool becomes loose and urgent That is why -diarrhea happens even after eating -there is no pain, fever, or infection -the problem continues for more than 6 months This condition corresponds to Pitta dominant grahani with Agni mandya (weak digestion) Drava atisara (watery stools) pakwashaya dushti (colon irritation) In simple words The stomach cannot digest properly, and the intestine cannot hold or absorb food correctly TREATMENT GOALS -calm the irritated intestine -restore digestive fire gently -stop diarrhea without blocking toxins -heal gut lining -prevent recurrence -make the body tolerate medicines again INTERNAL MEDICATIONS IMMEDIATE STEP STOP ZANDOPA Even if it helped earlier, Ayurveda strongly advises reassessment when -diarrhea becomes chronic -medicine itself triggers bowel irritation Restart only after gut stabilisation START 1) KUTAJGHAN VATI= 2 tabs twice daily after meals with rice gruel or warm water for 8 weeks =best for chronic diarrhea, reduces excess intestinal secretion, strengthens colon muscles, stop urgency without causing constipation 2) DADIMASHTAKA CHURNA= 1/2 tsp twice daily after meals with warm water =improves digestion gently, prevents food triggered diarrhea, reduces gas and bowel rush 3) BILVA AVALEHA= 1 tsp once daily after lunch =strengthens intestinal wall, improves stool consistency, nourishes gut tissue 4) YASHTIMADHU CHURNA= 1/4 tsp at bedtime with warm water =heals gut lining, reduces irritation and burning, prevents relapse EXTERNAL TREATMENT ABDOMINAL OIL MASSAGE= BALA OIL -massage gently around navel in circular motion, 5-7 minutes daily =calms vata, improves intestinal coordination, reduces bowel urgency DIET -rice gruel -soft cooked rice -moong dal -boiled vegetables- bottle gourd, ash gourd -thin buttermilk with roasted cumin -ripe banana AVOID -milk, panner, cheese, -curd at night -tea,coffee -spicy, fried foods -pickles, vinegar -bakery items -cold drinks Food must be warm, freshly cooked, and. simple HOME REMEDIES 1) POMEGRANATE PEEL DEOCTION -boil dried peel in water -reduce to half -drink 1-2 times daily 2) NUTMEG REMEDY -a pinch of nutmeg powder -with honey -once daily only 3) BUTTERMILK THERAPY -thin buttermilk -add roasted cumin + pinch of rock salt -once daily after lunch YOGA ASANAS -vajrasana after meals -pawanmuktasana -malasana -apanasana PRANAYAM -Anulom vilom= 10 rounds -Sheetali/sheetkari= for pitta calming -Bhramari= stress reduction AVOID -kapalbhati -bhastrika -excessive core workouts EXPECTED RECOVERY TIMELINE 2 WEEKS= stool frequency reduces 4 WEEKS= urgency improves 6-8 WEEKS= digestion stabilizes 3 MONTHS=medicine tolerance returns This condition is reversible It developed slowly, so it will Heal gradually Ayurveda does not suppress diarrhea suddenl- it restores intestinal intelligence With -correct medicines -diet discipline -lifestyle correction The gut regains strength, digestion normalises, and long term stability is achieved DO FOLLOW HOPE THIS MIGHT BE HELPFUL THANK YOU DR. MAITRI ACHARYA
HELLO, Your husband’s problem is not an infection, food poisoning, or sudden disease It is a functional digestive disorder that ha developed slowly over time WHAT ACTUALLY HAPPENED? -The digestive system works properly when the digestive fire is balanced -Long term continues use of mediicne (Zandopa) has gradually irritated the intestine and weakened digestion -Over months and years , the intestines became over-sensitive -Now whenever food or the medicine enters –the intestine reacts too fast –water is not absorbed properly –stool becomes loose and urgent That is why -diarrhea happens even after eating -there is no pain, fever, or infection -the problem continues for more than 6 months This condition corresponds to Pitta dominant grahani with Agni mandya (weak digestion) Drava atisara (watery stools) pakwashaya dushti (colon irritation) In simple words The stomach cannot digest properly, and the intestine cannot hold or absorb food correctly TREATMENT GOALS -calm the irritated intestine -restore digestive fire gently -stop diarrhea without blocking toxins -heal gut lining -prevent recurrence -make the body tolerate medicines again INTERNAL MEDICATIONS IMMEDIATE STEP STOP ZANDOPA Even if it helped earlier, Ayurveda strongly advises reassessment when -diarrhea becomes chronic -medicine itself triggers bowel irritation Restart only after gut stabilisation START 1) KUTAJGHAN VATI= 2 tabs twice daily after meals with rice gruel or warm water for 8 weeks =best for chronic diarrhea, reduces excess intestinal secretion, strengthens colon muscles, stop urgency without causing constipation 2) DADIMASHTAKA CHURNA= 1/2 tsp twice daily after meals with warm water =improves digestion gently, prevents food triggered diarrhea, reduces gas and bowel rush 3) BILVA AVALEHA= 1 tsp once daily after lunch =strengthens intestinal wall, improves stool consistency, nourishes gut tissue 4) YASHTIMADHU CHURNA= 1/4 tsp at bedtime with warm water =heals gut lining, reduces irritation and burning, prevents relapse EXTERNAL TREATMENT ABDOMINAL OIL MASSAGE= BALA OIL -massage gently around navel in circular motion, 5-7 minutes daily =calms vata, improves intestinal coordination, reduces bowel urgency DIET -rice gruel -soft cooked rice -moong dal -boiled vegetables- bottle gourd, ash gourd -thin buttermilk with roasted cumin -ripe banana AVOID -milk, panner, cheese, -curd at night -tea,coffee -spicy, fried foods -pickles, vinegar -bakery items -cold drinks Food must be warm, freshly cooked, and. simple HOME REMEDIES 1) POMEGRANATE PEEL DEOCTION -boil dried peel in water -reduce to half -drink 1-2 times daily 2) NUTMEG REMEDY -a pinch of nutmeg powder -with honey -once daily only 3) BUTTERMILK THERAPY -thin buttermilk -add roasted cumin + pinch of rock salt -once daily after lunch YOGA ASANAS -vajrasana after meals -pawanmuktasana -malasana -apanasana PRANAYAM -Anulom vilom= 10 rounds -Sheetali/sheetkari= for pitta calming -Bhramari= stress reduction AVOID -kapalbhati -bhastrika -excessive core workouts EXPECTED RECOVERY TIMELINE 2 WEEKS= stool frequency reduces 4 WEEKS= urgency improves 6-8 WEEKS= digestion stabilizes 3 MONTHS=medicine tolerance returns This condition is reversible It developed slowly, so it will Heal gradually Ayurveda does not suppress diarrhea suddenl- it restores intestinal intelligence With -correct medicines -diet discipline -lifestyle correction The gut regains strength, digestion normalises, and long term stability is achieved DO FOLLOW HOPE THIS MIGHT BE HELPFUL THANK YOU DR. MAITRI ACHARYA



