What is letrozole, and how does it help with fertility and hormone-related conditions?

Question

I recently heard about letrozole, and I was surprised to learn that it’s used both for fertility treatment and for certain cancers. I don’t fully understand how one drug can be used for such different conditions.

What exactly is letrozole, and how does it work in the body? I read that it’s an aromatase inhibitor—does that mean it lowers estrogen levels? Also, why is letrozole prescribed for women trying to conceive, and how does it compare to other fertility medications like Clomid?

I also want to know what the side effects of letrozole are. Does it cause hormonal imbalances, mood changes, or weight gain? Are there any Ayurvedic or natural treatments that help with fertility in a similar way to letrozole?

If anyone has taken letrozole for fertility or other health reasons, what was your experience? Did it help, and did you experience any side effects?

Dr. Harsha Joy · Accepted Answer

Letrozole is an aromatase inhibitor, which means it works by blocking the enzyme aromatase that converts androgens into estrogen. This lowers estrogen levels in the body, which is helpful in treating certain types of breast cancer by reducing the estrogen available for tumor growth. In fertility treatment, particularly for women with conditions like polycystic ovary syndrome (PCOS), letrozole helps stimulate ovulation. By lowering estrogen, it signals the brain to produce more follicle-stimulating hormone (FSH), leading to the development of eggs in the ovaries. Compared to Clomid, letrozole tends to have fewer side effects like thinning cervical mucus, and it may be better tolerated. However, side effects can include mood changes, hot flashes, and mild hormonal imbalances. In Ayurveda, herbs like Ashwagandha and Shatavari may be recommended to balance hormones and support fertility, but they work differently and may not have the same targeted effects as letrozole. Always consult with a healthcare provider before combining treatments.

What is letrozole, and how does it help with fertility and hormone-related conditions? - #14719

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