What Is Azathioprine Used For, and What Are Its Side Effects?

Question

I was recently prescribed Azathioprine, but I don’t fully understand what it does. From what I’ve read, Azathioprine is an immunosuppressant, but what exactly does that mean?

I know it’s commonly used for autoimmune diseases like rheumatoid arthritis, lupus, and Crohn’s disease, as well as for people who have had an organ transplant to prevent rejection. How does Azathioprine work to suppress the immune system, and how long does it take to show results?

One thing I’m worried about is the side effects of Azathioprine. I read that it can cause nausea, fatigue, increased risk of infections, and even liver toxicity. How common are these side effects, and do they go away over time, or do they require stopping the medication?

Are there any natural alternatives to Azathioprine that help with inflammation and autoimmune conditions? I’ve heard that Ashwagandha, Turmeric, and Boswellia might support the immune system—do these actually work alongside medication?

If anyone has taken Azathioprine, what was your experience? Did it help with your condition, and how did you manage any side effects?

Dr. Harsha Joy · Accepted Answer

Azathioprine is an immunosuppressant medication that works by inhibiting the production of certain immune cells, specifically T and B lymphocytes, which are involved in inflammation and the immune response. It’s commonly used to treat autoimmune diseases like rheumatoid arthritis, lupus, and Crohn’s disease, and also to prevent organ rejection after transplants. By suppressing the immune system, Azathioprine reduces the activity of these immune cells, which helps control inflammation and prevent damage to the body's tissues. The effects may take a few weeks to months to fully manifest. As for side effects, common ones include nausea, fatigue, increased susceptibility to infections, and potential liver toxicity, though these side effects don't occur in everyone. They may diminish over time or with dose adjustments, but severe side effects might require stopping the medication. While natural remedies like Ashwagandha, Turmeric, and Boswellia are known for their anti-inflammatory properties, they should not be seen as a substitute for immunosuppressive drugs and should only be used under the supervision of a healthcare provider to avoid interactions. If you’re taking Azathioprine, it's important to have regular check-ups to monitor for side effects and discuss any concerns with your doctor.

What Is Azathioprine Used For, and What Are Its Side Effects? - #15235

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