What Is the Urea Cycle, and How Does It Affect Kidney and Liver Health?

Question

I recently had some blood tests done, and my doctor mentioned that my urea cycle might not be functioning properly. I had never even heard of the urea cycle before, but after doing some research, I found out that it plays a huge role in how the body gets rid of waste, especially excess nitrogen.

From what I understand, the urea cycle happens in the liver, where ammonia (a toxic byproduct from protein metabolism) gets converted into urea and then eliminated through urine by the kidneys. But what happens when the urea cycle doesn’t work properly? Can it cause high ammonia levels in the blood?

I also read about urea cycle disorders, which can lead to fatigue, confusion, and even severe toxicity. But can a mild dysfunction in the cycle cause symptoms like sluggishness, headaches, or digestive issues? How would I even know if my urea cycle isn’t functioning properly?

Since I prefer natural approaches, I started looking into Ayurveda’s take on liver and kidney health. Are there Ayurvedic treatments or herbs that can support the urea cycle and help the body process waste more efficiently? I found that herbs like Punarnava, Bhumi Amla, and Gokshura are often used for kidney and liver detox—do they actually help?

For anyone who has had issues with their urea cycle, what was your experience? Did you make dietary changes, take supplements, or use herbal treatments to improve it? I’d love to understand how to support this process naturally and prevent complications.

Dr. Harsha Joy · Accepted Answer

The urea cycle is essential for converting ammonia, a toxic byproduct of protein metabolism, into urea, which is then excreted through urine. When this cycle doesn’t function properly, ammonia can accumulate in the bloodstream, leading to symptoms like fatigue, confusion, and in severe cases, toxicity. Mild dysfunction might cause more subtle symptoms like sluggishness, headaches, or digestive discomfort. If you suspect issues with the urea cycle, blood tests measuring ammonia levels can help determine if it’s functioning correctly. Ayurveda offers herbs that may support liver and kidney health, like Punarnava, Bhumi Amla, and Gokshura, known for their detoxifying and diuretic properties, which can aid in waste elimination. While these herbs are believed to support overall organ function, it’s important to work with your healthcare provider to properly diagnose and treat any urea cycle-related concerns. Adjusting diet and incorporating liver-friendly foods, such as those rich in antioxidants, might also help support the body's detoxification processes.

What Is the Urea Cycle, and How Does It Affect Kidney and Liver Health? - #15652

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